Is CYP11A1 critical for the vitamin D photoprotective system in skin? [ 2014 - 2016 ]

Research Grant

Researchers: Prof Rebecca Mason (Principal investigator) ,  A/Pr Robert Tuckey ,  A/Pr Vivienne Reeve ,  Dr Katie Dixon ,  Prof Gary Halliday

Brief description Sunlight produces DNA damage. When inadequately repaired, this damage produces skin cancer. The vitamin D system in skin helps protect against this skin damage, but the vitamin D compounds involved and how they work is unclear. Recent data shows new vitamin D compounds with photoprotective activity and that vitamin D compounds increased expression of DNA repair proteins. These studies may enable pharmacological enhancement of protection from sunlight.

Funding Amount $AUD 517,567.64

Funding Scheme Project Grants

Notes Standard Project Grant