CSF-1 regulation of macrophage adhesion and motility and promotion of tumour invasion and metastasis [ 2008 - 2010 ]

Also known as: Growth factor regulation of motility in a type of white blood cell, macrophages, and its effects on cancer spread

Research Grant

[Cite as]

Researchers: A/Pr Fiona Pixley (Principal investigator)

Brief description Macrophages, a type of white blood cell, infiltrate tumours and encourage tumour cells to metastasize. The mechanism involves secretion of a macrophage motility factor, CSF-1, by the tumour cells and secretion of a tumour cell motility factor by the macrophages to stimulate co-migration, invasion and metastasis. CSF-1 controls macrophage motility via the CSF-1 receptor. Dissection of receptor signalling pathways to macrophage motility will identify therapeutic targets to prevent tumour spread.

Funding Amount $AUD 323,453.08

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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