Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer [ 2008 - 2008 ]

Research Grant

Researchers: Prof Brendan Jenkins (Principal investigator) ,  A/Pr Ashley Mansell ,  A/Pr Richard Ferrero

Brief description Stomach cancer is the second most common cause of cancer-related deaths worldwide, and results in the yearly death of several thousand people in Australia alone. We have discovered a specific mutation in a gene called gp130 that results in the formation of gastritis and stomach cancer in mice. We are now aiming to understand the exact molecular events by which this mutation results in chronic inflammation and the subsequent uncontrolled growth of epithelial cells that line the stomach wall.

Funding Amount $AUD 174,800.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant