Counteracting age-associated neurodegenerative diseases using chaperone-based amyloid disaggregases [ 7/1/2021 - 6/30/2026 ]

Research Grant

Brief description In neurodegenerative diseases such as Alzheimer’s disease, proteins form clumps through changes in structure due to mutations or proteotoxic chemical insults. The formation of these toxic clumps causes brain cells to die prematurely triggering symptoms such as dementia. I have identified a molecular machine in human cells that efficiently clears these clumps. We are now developing strategies to activate this machine to repair damaged brain cells to slow/reserve neurodegenerative diseases.

Funding Amount $645,205

Funding Scheme Investigator Grants

Chief Investigator Dr Nadinath Nillegoda

Notes Emerging Leadership 1