Convergence of activated c-myb and Wnt pathways in colon cancer [ 2002 - 2004 ]

Research Grant

Researchers: Dr Theo Mantamadiotis (Principal investigator) ,  Dr Daphne Vogiagis ,  Prof Robert Ramsay

Brief description c-myb is essential for the normal biology of the blood system and the colon. It is involved in regulating the balance between the production of new cells and their timely removal once they have completed their assigned tasks. Another group of factors that make up theWnt pathway also contribute to the normal biology of the colon in man and mouse. Defects that lead to too much c-myb and ineffective control of the Wnt pathway appear to work together to increase the risk and severity of colon cancer. This project is designed to specifically test this observation in animals. In addition it examines in fine detail how c-myb levels increase in colon cancer and how it combines with the Wnt pathway to regulate other genes in colon cancer.

Funding Amount $AUD 256,320.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant