The contribution of subunit interfaces to receptor activation in ligand gated ion channels [ 2012 - 2015 ]

Research Grant

Researchers: Dr Trevor Lewis (Principal investigator) ,  E/Pr Peter Barry ,  Prof Peter Schofield

Brief description This project seeks to provide insights into new mechanisms that could be used to enhance or inhibit neuronal signalling. The family of pentameric neurotransmitter receptors that are key components in the process of neuronal signalling and are the target of this study. It will investigate the molecular motions that occur when the receptor shifts from the resting state to the activated state in the presence of neurotransmitter. This critical to understanding the normal function of these receptors in the brain and how they can be modulated.

Funding Amount $AUD 309,070.96

Funding Scheme Project Grants

Notes Standard Project Grant