grant

Contribution of nuclear targeting of the NleE-OspZ family of proteins to Escherichia coli and Shigella virulence [ 2009 - 2011 ]

Also known as: How bacteria cause diarrhoea

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/566639]

Researchers: Prof Elizabeth Hartland (Principal investigator)

Brief description This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified new bacterial proteins that allow E. coli to manipulate the normal host cell processes involved in killing an invading bacterium. Similar proteins are also present in the closely related organism, Shigella which causes dysentary. We will determine how these proteins act by finding the host cell proteins they bind.

Funding Amount $AUD 542,462.24

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Allergy | Biomedical and Clinical Sciences | Bacterial pathogen | Host-pathogen interaction | Immunology | Intestinal colonization | Shigellosis | bacterial gastroenteritis | inflammation | mucosal inflammation |
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