Contribution of MDSC-derived cysteine cathepsins in breast cancer metastasis to bone [ 2015 - ]

Research Grant

Researchers: Dr Laura Edgington-Mitchell (Principal investigator)

Brief description Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.

Funding Amount $309,436.00

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF