Consequences of Waveform Composition for Epithelial Integrity and Homogeneous Ventilation during HFOV [ 2011 - 2013 ]

Also known as: Characteristics of Pressure Waveforms that Optimise Gas Exchange and Minimise Airway Injury during High Frequency Ventilation

Research Grant

[Cite as]

Researchers: A/Pr Jane Pillow (Principal investigator) ,  Prof Andrew Bassom A/Pr David Tingay

Brief description High-frequency oscillation (HFO) delivers up to 900 breaths/minute to newborn babies. In theory, the tiny HFO breaths decrease ventilator induced lung injury whilst efficiently delivering oxygen to and removing waste gas from the blood. However, HFO may damage the large airways due to the high gas flows. We will use mathematical models and studies in preterm lambs to assess how to optimise distribution of fresh gas to the lung while minimising any airway damage. Our findings will help doctors treat preterm babies with lung disease.

Funding Amount $AUD 409,483.41

Funding Scheme Project Grants

Notes Standard Project Grant

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