Congestive heart failure: a longitudinal study of its impact on brain function and structure in later life. [ 2006 - 2008 ]

Research Grant

Researchers: Prof Osvaldo Almeida (Principal investigator) ,  A/Pr Christopher Etherton-Beer ,  Prof Leon Flicker ,  Prof Leonard Arnolda ,  Prof Nicola Lautenschlager

Brief description This project aims to clarify the long-term impact of congestive heart failure (CHF) on brain function and structure. CHF is a common complication of most diseases of the heart, with over 30,000 new cases being diagnosed annually in Australia. Of all CHF hospitalisations, 75% are made up of people aged 70 years or over. Consequently, as the Australian population ages, the number of people with CHF is expected to rise sharply. CHF is associated with increased mortality and significant morbidity. It also impacts upon quality of life in other ways. The daily life of patients is often limited by the direct effects of CHF, such as exertional dyspnoea, fatigue and weakness; associated medical conditions, such as ischaemic heart disease, hypertension and diabetes, as well as depression and memory impairment. Of note, cognitive impairment is a leading cause of years of life lost due to disability in Australia. This project aims to clarify the factors that contribute to the development of cognitive deficits in people with CHF. Its results should serve as a basis for the development of effective preventative strategies to halt or slow down the development of such deficits. In addition, we expect that the findings of the study will improve our understanding of other common disorders associated with cognitive decline in later life, such as Alzheimer's disease.

Funding Amount $AUD 612,130.60

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant