Conditional knockout of the murine patched gene for the study of skin differentiation and cancer. [ 2001 - 2003 ]

Research Grant

Researchers: Prof Brandon Wainwright (Principal investigator)

Brief description Basal cell carcinoma (BCC) is the most common cancer in Australia. We recently isolated the BCC gene, Patched (PTCH) from analysis of patients with Naevoid Basal Cell Carcinoma Syndrome (NBCCS). Individuals with NBCCS have a wide variety of developmental defects in addition to a cancer predisposition which includes medulloblastoma, rhabdomyosarcoma and ovarian fibroma as well as multiple BCCs. This application proposes the generation of an animal model for skin development and cancer by selectively removing patched gene function from specific cell of the skin. In doing this we will be able to determine the exact role of this gene in skin development, and how mutation causes common skin cancer.

Funding Amount $AUD 423,564.26

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant