Computational reconstruction and validation of a gene regulatory network controlling differentiation of B cells to antibody-secreting plasma cells [ 2017 - 2019 ]

Research Grant

Researchers: Dr Wei Shi (Principal investigator) ,  Dr Melissa Davis ,  Prof Axel Kallies

Brief description Regulation of B cell differentiation, which occurs when our body responds to antigen infection is tightly controlled by a gene regulatory network. This project will be the first study to reconstruct a regulatory network for this process by using genome-wide expression and transcription factor binding data. The research finding from this study will elucidate the molecular mechanisms regulating this process and will shed new light on how this network is altered in lymphoma and myeloma.

Funding Amount $AUD 632,750.98

Funding Scheme Project Grants

Notes Standard Project Grant