grant

Clinical implications of IL7R genotype: from disease risk to disease management [ 2013 - 2016 ]

Also known as: Clinical significance of IL7R genotype

Funded by National Health and Medical Research Council
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1050074]

Researchers: Prof Graeme Stewart (Principal investigator) ,  Dr Fiona Mckay ,  Ms Reena Rajasuriar ,  Prof David Booth ,  Prof David Gottlieb
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Brief description We’ve identified a genetic test (IL7R?) that may predict and prevent the risk of patients (i) failing to respond adequately to treatment for HIV (ii) who are at high risk of death after bone marrow transplantation and (iii) who fail to respond to interferon treatment for MS. This project aims to confirm these in very large patient groups and uncover the cellular basis for the genetic effect. Our goal is to provide a novel test that will improve patient outcomes in 3 serious disease states.

Funding Amount $AUD 627,765.07

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Biological Sciences | CD4 | Genetics | Genetic Immunology | antiretroviral therapy | bone marrow transplantation | genetics | human immunodeficiency virus (HIV) | interferon non-responders | interleukins (IL) | multiple sclerosis (MS) | pharmacogenomics | regulatory T cells |
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