grant

Cis regulatory and functional analysis of genomic loci with implication in hypothalamic obesity using the zebrafish as a model system [ 2011 - 2014 ]

Also known as: Gene regulatory defects in hypothalamic obesity

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1010713]

Researchers: Dr Silke Rinkwitz (Principal investigator) ,  Prof Thomas Becker

Brief description Gene regulatory mutations cause changes in gene activity (expression -level, -time, -site) and therefore decide about the availability of proteins. Regulatory mutations in uncharacterized genomic loci that are related to obesity and further their effects shall be identified, with emphasis on those affecting the hypothalamic food intake control circuits. Since the energy metabolism system and the obesity candidate genes are conserved, the model system zebrafish will be used for these analyses.

Funding Amount $AUD 480,936.18

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biological Sciences | Genetics | Neurogenetics | gene regulation | genetic disorders | genetic predisposition | hypothalamus | neuroendocrine differentiation | neurological diseases | obesity | transgenesis | zebrafish |
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