Circulating tumour DNA (ctDNA) to guide adjuvant chemotherapy and surveillance strategies in patients with stage II colon cancer [ 2015 - 2019 ]

Research Grant

Researchers: Prof Peter Gibbs (Principal investigator) ,  Prof Bert Vogelstein

Brief description This study is attempting to demonstrate that an adjuvant therapy strategy based on ctDNA results will reduce the number of patients with stage II colon cancer receiving adjuvant chemotherapy without compromising recurrence free survival. Prospective multi-centre study enrolling 450 stage II colon cancer patients. Patients will be randomized 2:1 to be treated according to ctDNA results (Arm A, n = 300), or per standard clinical criteria (Arm B, n = 150).

Funding Amount $AUD 1,227,186.88

Funding Scheme Project Grants

Notes Standard Project Grant