Cholestasis and hepatocyte injury in chronic liver disease [ 2017 - ]

Research Grant

Researchers: Prof Narcissus Teoh (Principal investigator) ,  A/Pr Anselm Enders ,  Prof Geoffrey Farrell

Brief description The aim of this project is to understand the consequences of long-term cholestasis or impaired bile excretion/flow on normal liver cells (hepatocytes) and to test whether specific bile acids can cause irreversible damage to hepatocytes leading to their transformation into pre-malignant cells and hepatocellular carcinoma (primary liver cancer). The results from this project will inform new strategies in screening, prevention and treatment of liver cancer in children and adults with cholestasis.

Funding Amount $615,967.00

Funding Scheme Project Grants

Notes Standard Project Grant