grant

Chemokines in osteoclast differentiation [ 2008 - 2010 ]

Also known as: Early induction of a chemokine autocrine loop is necessary for osteoclast formation.

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/481946]

Researchers: A/Pr Nigel Morrison (Principal investigator)

Brief description Chemokines are small molecules that are released by a number of cell types, particularly monocytes, when inflammation occurs. Chronic inflammatory disease is associated with severe bone erosion and loss of bone quality. Surprisingly, chemokines control osteoclast development as well as macrophage activation; even if the osteoclast has formed, blocking chemokine signalling prevents bone resorption. Chemokines are a new and exciting target to control osteoclast formation.

Funding Amount $AUD 424,288.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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