Chemical and structural biology validation of Lamin B1 as a new anti-cancer target [ 2014 - 2016 ]

Research Grant

Researchers: A/Pr Guillaume Lessene (Principal investigator) ,  Dr Nadia Kershaw ,  Prof Maria Kavallaris

Brief description The validation of new anti-cancer targets is critical for the development of new therapies. We have discovered a small molecule that disrupt the function Lamin B1 during cell division and decreases tumour growth significantly in vivo. With this research proposal, we will investigate the role that Lamin B1 exerts during cell division and why interfering with this protein has such a profound impact on cancer cells.

Funding Amount $AUD 638,272.05

Funding Scheme Project Grants

Notes Standard Project Grant