Characterization and targeting of precursor exhausted T cells (TPEX) for the treatment of chronic infection and cancer [ 1/1/2021 - 12/31/2025 ]

Research Grant

Brief description The recent discovery of precursor exhausted CD8 T cells (TPEX) has not only allowed us to conceptualize our understanding of how chronic T cell responses are maintained over long periods of time, but also resulted in a new understanding of the mechanisms underpinning checkpoint inhibition. I will undertake critical characterization of these TPEX in chronic viral infections with the goal to reveal phenotypic and functional properties, which will serve as potential novel targets for immunotherapy.

Funding Amount $606,009

Funding Scheme Investigator Grants

Chief Investigator Dr Daniel Utzschneider

Notes Emerging Leadership 1