grant

Characterization ol a novel covalently cross -linked Abeta peptide dimer and its role in Alzheimers Disease. [ 2009 - 2012 ]

Also known as: Dityrosine-linked Abeta peptide in Alzhiemers Disease

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/566980]

Researchers: Dr Giuseppe Ciccotosto (Principal investigator) ,  Dr David Bowser

Brief description Currently there are limited therapeutic treatments and no cure for Alzheimer's disease (AD). The key protein causing AD is called Abeta. Abeta peptides form dityrosine cross-linked dimers (when 2 peptides join together) and this is thought to be responsible for killing brain cells in AD. Therefore, this proposal will determine the role of Abeta dimers in relation to killing brain cells and the progression of AD through analysis of their biological and biochemical properties.

Funding Amount $AUD 553,236.30

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Alzheimer's Disease | Alzheimer's disease | Alzheimer's disease and normal aging | Biomedical and Clinical Sciences | Medical Infection Agents (Incl. Prions) | Medical Microbiology | beta amyloid | lipids | neurodegeneration | neurodegenerative and age-related diseases | neurotoxicity |
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