grant

Characterization of a novel IFNbeta signaling axis mediated via IFNAR1 [ 2014 - 2016 ]

Also known as: Novel IFNbeta signaling axis

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1070782]

Researchers: Dr Nicole De Weerd (Principal investigator)

Brief description Type I interferons (IFNs) play an important role in regulating immune responses to pathogens and tumors and are used therapeutically. This project will investigate a novel IFN signaling axis that we have recently characterized that is mediated via the low affinity IFN receptor, IFNAR1. This signaling axis occurs independently of the high affinity IFN receptor IFNAR2 and contributes to lethality in a model of septic shock.

Funding Amount $AUD 353,754.90

Funding Scheme Project Grants

Notes New Investigator Grant

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