Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways [ 2016 - 2018 ]

Research Grant

Researchers: Prof Bostjan Kobe (Principal investigator) ,  A/Pr Ashley Mansell ,  A/Pr Mehdi Mobli

Brief description The innate immune system is the first line of defence against pathogens. Inhibitors of innate immune pathways can be developed into therapeutic agents against a number of disorders including chronic inflammatory diseases, such as rheumatoid arthritis. We have discovered a new mechanisms of signaling by a set of key molecules in these pathways, through formation of large assemblies. We will characterize these assemblies and uncover ways to inhibit their formation.

Funding Amount $AUD 732,260.20

Funding Scheme Project Grants

Notes Standard Project Grant