grant

Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways [ 2016 - ]

Also known as: 5011436

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/GNT1107804]

Researchers: Prof Bostjan Kobe (Principal investigator) ,  A/Pr Ashley Mansell A/Pr Mehdi Mobli Dr Thomas Ve

Brief description The innate immune system is the first line of defence against pathogens. Inhibitors of innate immune pathways can be developed into therapeutic agents against a number of disorders including chronic inflammatory diseases, such as rheumatoid arthritis. We have discovered a new mechanisms of signaling by a set of key molecules in these pathways, through formation of large assemblies. We will characterize these assemblies and uncover ways to inhibit their formation.

Funding Amount $711,995.00

Funding Scheme Project Grants

Notes Standard Project Grant

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