Characterising the tumour suppressive function of myoepithelial cell stefin A in ductal carcinoma in situ [ 2017 - 2019 ]

Research Grant

Researchers: Dr Belinda Parker (Principal investigator) ,  Prof Gregory Mann ,  Prof Sandra Otoole

Brief description Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer, whereby the tumour cells remain restrained by myoepithelial cells that surround breast ducts. Predicting which cases of DCIS will later develop invasive cancer is difficult, meaning that the majority of patients have treatment. Stefin A is a protease inhibitor in myoepithelial cells shown to block cancer invasion and we aim to test the function of this protein in DCIS and its potential as a prognostic marker.

Funding Amount $AUD 486,029.38

Funding Scheme Project Grants

Notes Standard Project Grant