Characterising the role of streptokinase polymorphism in invasive pathogenesis of Streptococcus pyogenes. [ 2009 - 2012 ]

Also known as: Characterisation of streptokinase polymorphism in Streptococcus pyogenes

Research Grant

[Cite as]

Researchers: Dr Jason Mcarthur (Principal investigator)

Brief description Invasive bacterial pathogens such as Streptococcus pyogenes, can hijack host proteins and use them to facilitate the disease process. S. pyogenes secrete streptokinase to activate a host protease (plasminogen) which is used by the bacterium to invade through host tissue. This project will characterise the molecular mechanisms involved in streptokinase mediated activation of plasminogen which will assist the generation of novel therapeutics to treat invasive diseases.

Funding Amount $AUD 480,535.54

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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