grant

Characterising a novel molecular pathway to reduce penicillin failure for Strep throat

Also known as: Ideas Grants

Funded by National Health and Medical Research Council
Managed by The University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/2020543]

Funding Amount $819,804.00

Full description Strep throat is a common bacterial infection caused by Group A Streptococcus (GAS). While GAS is sensitive to penicillin in vitro, 10-20% of infections recur after treatment. We have identified that some GAS strains can replicate in a penicillin-resistant intracellular niche. This project will define this mechanism of resistance to penicillin and other antibiotics, and develop a prototype test to detect resistant infections at the point of care. This will lead to better treatment outcomes.

Chief Investigator Dr Timothy Barnett

Date Announced 2022-12-14T00:00:00

Sector University

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Spatial Coverage And Location

text: WA

Subjects
Basic Science Research | Medical and Health Sciences | Medical Microbiology | Medical Bacteriology | antibiotic resistance | antibiotic use | bacterial pathogenesis | biomedical and clinical sciences | group a streptococcal disease | intracellular bacterial infections |
Identifiers
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ACN 633 798 857