grant

Characterising the effects of oxidative stress on the human L-type Ca2+ channel isoforms and role in human pathology [ 2011 - 2016 ]

Also known as: How do free radicals and altered calcium transport in human heart cause heart disease

Funded by National Health and Medical Research Council
Managed by The University of Western Australia
Managed by University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1002207]

Researchers: A/Pr Livia Hool (Principal investigator)

Brief description Oxidative stress, poor energy production and increases in intracellular calcium are features of the failing heart. I have determined that the function of the L-type calcium channel, the primary protein responsible for calcium influx and contraction can be regulated by free radicals produced by the mitochondria (powerhouse of the cell). This proposal will determine the site of modification on the human L-type calcium channel and how communication between the channel and the mitochondria is altered in animal models of human disease.

Funding Amount $AUD 250,805.41

Funding Scheme Research Fellowships

Notes Research Fellowship

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Aboriginal health | Cardiorespiratory Medicine and Haematology | Cardiology (Incl. Cardiovascular Diseases) | Medical and Health Sciences | calcium | calcium channels | cardiac disease | cardiac hypertrophy | mitochondria | oxidative stress | prevention |
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