Characterising the beta-catenin nuclear targeting pathway in cancer [ 2013 - 2015 ]

Also known as: Novel mechanisms of beta-catenin nuclear import in cancer

Research Grant

[Cite as]

Researchers: A/Pr Beric Henderson (Principal investigator) ,  Prof Jade Forwood A/Pr Mark Molloy Dr Manisha Sharma

Brief description Bowel cancer is caused by inherited gene mutations that cause build-up of beta-catenin protein in the cell nucleus. Bowel cancer is the second largest cause of cancer deaths in Australia. We aim to study the mechanisms controlling beta-catenin accumulation in the nucleus. We will characterise new signalling pathways that control movement and activity of beta-catenin in the nucleus. This will yield insights into the role of beta-catenin in cancer and possible targets for therapy.

Funding Amount $AUD 485,081.54

Funding Scheme Project Grants

Notes Standard Project Grant

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