Characterisation and therapeutic targeting of molecular pathways that promote breast cancer metastasis to bone [ 2009 - 2014 ]

Research Grant

Researchers: Dr Belinda Parker (Principal investigator)

Brief description Breast cancer that has spread to bone cannot be cured. Using the most clinically relevant model of breast cancer available we have identified that tumour cells growing in bone need to suppress immune elimination (by suppressing the Type I interferons) and invade through the bone tissue (by activation of cysteine cathepsins). Studying the functional role of these pathways will provide novel insight into the mechanisms of breast cancer spread to bone that can be augmented therapeutically.

Funding Amount $AUD 442,573.45

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF