Characterisation of SRY Macromolecular Complexes to Provide an Enhanced Understanding of Human Genetic Sex Reversal and Embryonic Sex Determination [ 2012 - 2015 ]

Research Grant

Researchers: Prof Jade Forwood (Principal investigator)

Brief description SRY is the most important gene in the determination of human sex. Mutations in the SRY gene that disrupt its ability to interact with other cellular proteins that regulate its function have shown to result in genetic sex reversal. This project will provide a detailed structural profile of the interfaces that are critical for sex determination, provide a molecular basis for XY-genetic sex reversal, and an enhanced understanding of foetal development.

Funding Amount $AUD 237,360.96

Funding Scheme Project Grants

Notes New Investigator Grant