Characterisation of the morning surge of blood pressure as a risk factor for cardiovascular disease. [ 2005 - 2007 ]

Research Grant

Researchers: Prof Geoffrey Head (Principal investigator) ,  Prof Barry Mcgrath

Brief description Cardiovascular events occur more frequently in the early morning transition between the asleep and awake state. This parallels the period where the rise in blood pressure and heart rate is at its greatest and hence may be a potential risk marker for cardiovascular events. We have developed a new mathematical way of measuring the morning surge in blood pressure and heart rate in patients using ambulatory monitoring which has been patented. The main aim of the grant is to determine if morning blood pressure surge is a risk factor and to determine the underlying mechanisms. Using both clinical and experimental studies we aim to a) characterise the rate of morning rise in hypertension and normotension b) determine whether subjects with an exaggerated morning surge in blood pressure also have an over responsive nervous system, c) determine whether the rate of rise in blood pressure is a risk factor and d) determine in stroke prone animals whether preventing the waking blood pressure surge is beneficial. This will be achieved via a novel analysis method of continuous BP recording over the 24hr period. These studies are important since identification of new risk markers or predictors of sudden cardiac death, stroke and myocardial infarction is a national health priority. Understanding the mechanisms that are responsible for the increased risk of a cardiovascular event in the morning is the first step to devising appropriate treatment and risk management. Our study will shed light on both the mechanism and the therapy aspects.

Funding Amount $AUD 399,450.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant