grant

Characterisation of antigenic variation of Neisserial cell surface adhesins, and their role in infection [ 2009 - 2012 ]

Also known as: Investigations into how bacterial cell surface structures vary, and the effect this has on the ability to cause disease

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/546003]

Researchers: Prof John Davies (Principal investigator) ,  A/Pr Charlene Kahler

Brief description A group of bacteria called Neisseria cause human-specific infections. They produce two types of surface proteins termed adhesins, which allow the bacteria to adhere to, and invade, human cells. There is circumstantial evidence to suggest the bacteria can rapidly vary the structure of these adhesins, even within a single infection. This project will determine whether, and how, this variation is occurring, and what effect it has on the ability of the bacteria to cause disease.

Funding Amount $AUD 556,983.66

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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