Research Grant
[Cite as http://purl.org/au-research/grants/nhmrc/251575]Researchers: Prof Eleanor Mackie (Principal investigator) , Prof Robert Pike
Brief description Many diseases of bones, such as osteoporosis and delayed fracture repair, result from the abnormal function of bone cells. Factors regulating bone cell function are, therefore, important in maintaining a healthy skeleton, as well as in the skeleton's response to disease. The enzyme thrombin is involved in blood coagulation but also causes bone cells to alter their behaviour. Thrombin stimulates proliferation of bone-forming cells and protects them from premature death. Thrombin also stimulates the breakdown of bone. We will investigate how thrombin's effects on bone cell behaviour influence the course of bone healing. We will also determine how thrombin stimulates bone breakdown and increases survival of bone-forming cells. This study will contribute to the understanding of how bone cells function in health and disease.
Funding Amount $AUD 120,775.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/251575
- nhmrc : 251575