grant

Cellular responses to oligodendrcyte apoptosis: modeling the early pathogenesis of Multiple Sclerosis [ 2010 - 2012 ]

Also known as: Understanding how the brain responds to cell loss in Multiple Sclerosis

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/628749]

Researchers: Dr Tobias Merson (Principal investigator)

Brief description In Multiple Sclerosis, oligodendrocytes (the myelin-producing cells of the brain) are damaged and myelin is lost. This process results in damage to nerve cells. We have generated a model of oligodendrocyte death that results in nerve cell damage. We will use this model to understand how nerve cells become damaged when oligodendrocytes die and whether the brain can make new oligodendrocytes to protect nerve cells from further damage.

Funding Amount $AUD 460,037.79

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
CNS repair after injury | Demyelination | Medical and Health Sciences | Microglia | Multiple sclerosis | Neurosciences | Neurology and Neuromuscular Diseases | Neuronal injury | Oligodendrocyte | central nervous system demyelination and inflammation | disease models, animal | multiple sclerosis | neurodgenerative disease |
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