Cellular and molecular regulation of interhemispheric fusion [ 2013 - 2015 ]

Research Grant

Researchers: Prof Linda Richards (Principal investigator)

Brief description In the developing brain, the two cerebral hemispheres undergo interhemispheric fusion to allow commissural fibres to cross the midline. Lack of interhemispheric fusion results in agenesis of the corpus callosum and may manifest as an interhemispheric cyst in acallosal patients. This project will investigate the cellular and molecular mechanisms that regulate interhemispheric fusion, including removal of the leptomeninges, astroglial differentiation and the formation of adherens junctions at the interhemispheric fissure to mediate fusion.

Funding Amount $AUD 449,489.89

Funding Scheme Project Grants

Notes Standard Project Grant