Cellular and molecular mechanisms of Hedgehog signaling in breast cancer [ 2013 - 2015 ]

Research Grant

Researchers: A/Pr Alexander Swarbrick (Principal investigator) ,  Prof Sandra Otoole

Brief description Breast cancer cells create the conditions for their own survival by communicating their needs to the healthy cells that surround them. We have previously shown that a molecule known as ‘hedgehog’ transmits biochemical signals between breast cancer cells and healthy cells. When hedgehog is ‘silenced’, tumours shrink and stop their spread. In this application, we will identify the cells receiving the hedgehog signal and identify how they support the growth and spread of breast cancers.

Funding Amount $AUD 551,937.24

Funding Scheme Project Grants

Notes Standard Project Grant