Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases [ 2011 - 2013 ]

Research Grant

Researchers: Prof Glenda Halliday (Principal investigator) ,  Prof Brett Garner ,  Prof Ellen Sidransky

Brief description Approximately 1 in 100 people are carriers of mutations in the glucocerebrosidase (GBA) gene and are at considerably greater risk of diseases characterised clinically by parkinsonism and by the presence of Lewy body-related pathology. This study will provide tissue-based evidence of the cellular lipid and protein changes relating to Lewy body formation in patients with GBA mutations, providing the information necessary to identify the pathways and mechanisms involved.

Funding Amount $AUD 524,820.33

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant