Cell Death Pathways and Type 1 Diabetes [ 2007 - 2012 ]

Research Grant

Researchers: Prof Joseph Trapani (Principal investigator) ,  A/Pr Helen Thomas ,  Dr Janette Allison ,  Prof Andreas Strasser ,  Prof Thomas Kay

Brief description Loss of insulin-producing beta cells leads to type 1 diabetes and rejection of allogeneic islet transplants. The aim of this program is to discover ways of protecting beta cells from damage. We will do this by investigating whether blocking crucial regulators of cell death can protect mouse and human beta cells from destruction in vitro and in vivo. In doing so, we aim to prevent diabetes in mice and potentially improve the survival of islet grafts after transplantation.

Funding Amount $AUD 3,029,962.28

Funding Scheme NHMRC Strategic Awards

Notes Diabetes Collaborative Research Grants