CAPTURE: Circulating tumour DNA assessment of PIK3CA to guide treatment response [ 2018 - ]

Research Grant

Researchers: A/Pr SarahJane Dawson (Principal investigator) ,  A/Pr Meredith Regan ,  A/Pr Nicholas Wilcken ,  A/Pr Prudence Francis ,  Prof Sherene Loi

Brief description Many breast cancers shed small amounts of DNA (called circulating tumor DNA or ctDNA) into the patient’s bloodstream. This proposal is for a clinical trial which will examine the use of ctDNA to follow levels of a specific therapeutic target (a mutation in a gene called PIK3CA) in blood, to allow the timely introduction of a targeted therapy (PI3K inhibitor). The trial aims to lead to improved outcomes for women with estrogen receptor positive metastatic breast cancer.

Funding Amount $3,299,064.00

Funding Scheme Project Grants

Notes Standard Project Grant