The calcium channel TRPV4 in skeletal development and arthritis [ 2012 - 2014 ]

Research Grant

Researchers: A/Pr Shireen Lamande (Principal investigator) ,  Prof Christopher Little ,  Prof John Bateman ,  Prof Peter Mcintyre

Brief description We have discovered that mutations in a calcium channel gene, TRPV4, cause an inherited osteoarthritis in the hands and feet. This work suggests that TRPV4 may be important in osteoarthritis and suggests the exciting possibility that modulating TRPV4 activity may provide a new therapeutic approach for arthritis. We will study how and why the mutations disrupt channel function and study mouse models to see if they are more or less susceptible to arthritis.

Funding Amount $AUD 683,069.06

Funding Scheme Project Grants

Notes Standard Project Grant