grant

Bone-specific sclerostin and SIBLING proteins in osteoarthritis: novel contributions to cartilage and bone pathology [ 2010 - 2011 ]

Also known as: Novel bone proteins contribute to osteoarthritis

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/607399]

Researchers: Prof John Bateman (Principal investigator) ,  Prof Christopher Little Prof Philip Sambrook

Brief description Arthritis is a major clinical problem and involves the destruction of cartilage in joints. However, the mechanisms of how this cartilage destruction is initiated and progresses remain poorly understood. We recently discovered that that three proteins that play a role in bone are also produced in cartilage and are increased in cartilage during osteoarthritis. We will determine the role of each of these in the disease mechanism to provide new therapeutic and biomarker targets.

Funding Amount $AUD 441,058.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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