Why is the bone marrow a “hot-spot” for myeloma plasma cell metastasis: are there Gremlins in the system? [ 2016 - ]

Research Grant

Researchers: Prof Andrew Zannettino (Principal investigator) ,  A/Pr Daniel Worthley ,  A/Pr Siddhartha Mukherjee ,  A/Pr Simon Leedham ,  Dr Lynn Fink
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Brief description Most cancer patients die because their cancer spreads from a primary site to other tissues in the body. Once escaping the primary site, 70% of all tumours will spread to bone. This raises the question, why is bone a preferred destination for cancer cells? We provide evidence that Gremlin1, made by non-cancer cells within bone, is a key protein that supports cancer growth. This study will examine whether inhibiting Gremlin1 is a potential therapy to inhibit cancer spreading to bone.

Funding Amount $651,979.00

Funding Scheme Project Grants

Notes Standard Project Grant