Bone marrow Endothelial Stem Cells have the capacity to form both the endothelial and haemopoietic hierarchies [ 2015 - ]

Research Grant

Researchers: Prof Susan Nilsson (Principal investigator) ,  A/Pr David Curtis ,  Prof Jose Polo

Brief description Blood cell formation is hierarchically organised; with hemopoietic stem cells (HSC) responsible for producing mature circulating blood cells. HSC reside in marrow near blood vessel cells. Although these play a key role in HSC regulation their origin in adults is poorly understood. We have demonstrated the existence of adult marrow vessel stem cells at the apex of a parallel hierarchy. Our objective is to characterise these in mice and humans and determine their role in blood malignancies.

Funding Amount $1,394,125.00

Funding Scheme Project Grants

Notes Standard Project Grant