Can Blockade of Leptin Action in the Brain reduce Blood Pressure in Obese Mice? [ 2012 - 2014 ]

Research Grant

Researchers: Prof Michael Cowley (Principal investigator) ,  Dr Pablo Enriori ,  Dr Russell Brown

Brief description The aim of these studies is to determine if high leptin levels in obese mammals activate the sympathetic nervous system (SNS), and thereby contribute to pathologically high blood pressure, increased heart rate and diabetes. If so, it may be possible to develop novel therapeutics to acutely improve a patient's metabolic condition, by blocking leptin action. The obese are already insensitive to the anorectic actions of leptin, so blocking leptin would likely have no deleterious consequences.

Funding Amount $AUD 653,049.62

Funding Scheme Project Grants

Notes Standard Project Grant