Biology of the novel C-type lectin receptor DCL-1 in innate and adaptive immune response [ 2005 - 2007 ]

Research Grant

Researchers: Dr Masato Kato (Principal investigator) ,  Prof Derek Hart

Brief description The innate immune system is the first line of defense in protecting the body from infection. Phagocytic (meaning eating) white blood cells, which include dendritic cells and macrophages are equipped with cell surface proteins These bind the many types of microbes that cause infection, allowing the phagocytes to destroy them (innate immune response). Furthermore, dendritic cells and macrophages have mechanisms to activate additional specific responses (adaptive immune response) mediated by lymphocytes (T and B cells). We have discovered a cell surface protein, termed DCL-1, which may play a role in uptake of microbes by phagocytes and activation of innate and adaptive immune responses. This project will examine the mechanisms whereby DCL-1 mediates these immune responses. Understanding the mechanism may allow us to exploit DCL-1 for tumor immunotherapy.

Funding Amount $AUD 439,500.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant