To Biochemically Trick P-Glycoprotein (Pgp) to Target Resistance via Lysosomal Pgp [ 2018 - 2020 ]

Research Grant

Researchers: Prof Des Richardson (Principal investigator) ,  Dr Danuta Kalinowski ,  Prof Paul Bernhardt

Brief description We have discovered an innovative biochemical strategy whereby our novel compounds exploit and trick a part of the detoxification machinery, that is the transporter, P-glycoprotein, to specifically kill drug resistant cancer cells. Herein, we take advantage of this biochemical mechanism to design novel and safe drugs to selectively target resistant tumours.

Funding Amount $AUD 612,301.86

Funding Scheme Project Grants

Notes Standard Project Grant