grant

Biochemical reconstitution of the ubiquitin ligase pathway defective in Fanconi Anaemia [ 2012 - 2014 ]

Also known as: Biological basis of the cancer predisposition disorder Fanconi Anaemia

Funded by National Health and Medical Research Council
Managed by St. Vincent's Institute of Medical Research
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1031104]

Researchers: Dr Andrew Deans (Principal investigator)

Brief description Fanconi Anemia (FA) is characterised by loss of vital blood cells but also 700x risk of developing leukaemia and other cancers. FA is caused by an inherited defect in one of 15 different genes that provide a signal and repair mechanism protecting cells from cancer causing mutations. By reconstructing this signaling mechanism in the test tube we will determine how it contributes to cancer protection, and highlight potential strategies for treatment of FA and leukaemia in the general population.

Funding Amount $AUD 562,742.09

Funding Scheme Project Grants

Notes New Investigator Grant

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Subjects
Biochemistry and Cell Biology | Biological Sciences | DNA damage | DNA repair | Enzymes | breast cancer | enzyme-protein interactions | genetic disorders | leukaemia | protein complexes | protein modification |
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