Biochemical and molecular dissection of the mechanisms controlling ribosome biogenesis by the PI3K/AKT/mTOR/MYC network [ 2011 - 2013 ]

Research Grant

Researchers: Prof Richard Pearson (Principal investigator) ,  Prof Ross Hannan

Brief description Ribosome synthesis and function are critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely, de-regulated cell growth can lead to cancer. We have identified new roles for the AKT and SGK families of kinases in controlling this process. This proposal aims to establish the mechanisms by which these enzymes control ribosome synthesis to better understand growth control and to provide insight for targeting these pathways in growth driven cancers.

Funding Amount $AUD 545,180.33

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant