Bcl-2 proteins and the regulation of the megakaryocyte lineage. [ 2009 - 2011 ]

Research Grant

Researchers: Prof Andrew Roberts (Principal investigator) ,  Prof Benjamin Kile (Principal investigator) ,  Dr Chloe James

Brief description Platelets are tiny cells that circulate in the blood. They are essential for blood clotting. Too few platelets leads to uncontrolled bleeding. Platelets are produced in the bone marrow by cells called 'megakaryocytes'. Cancer chemotherapy often causes dangerous decreases in platelet count - this is thought to be because it kills megakaryocytes. We will pinpoint the molecules responsible for megakaryocyte life and death. This has the potential to make the side effects of chemotherapy less severe.

Funding Amount $AUD 416,240.07

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant