How BANK1 pathway defects in B cells cause human lupus [ 2017 - 2021 ]

Research Grant

Researchers: Prof Carola Vinuesa (Principal investigator) ,  Dr Anselm Enders

Brief description Autoimmune diseases affect 1 in 20 Australians and are incurable. To find effective therapies, we need to understand the genes that cause disease in humans. We have sequenced the entire genome of patients with an autoimmune disease and found several patients carrry two mutations in genes important for activation of B cells and shown these mutations cause disease. We plan to understand how these genes prevent autoimmunity, and to identify the best treatment for patients with these mutations.

Funding Amount $AUD 1,350,661.73

Funding Scheme Project Grants

Notes Standard Project Grant